含羞草研究所 Downstate Researchers Find that Memory Storage Molecule Preserves Complex Memories:
Dec 23, 2008
Contact: Andre Fenton 鈥� 718-270-1556
andre.fenton@downstate.edu
Ron Najman 鈥� 718-270-2696
ron.najman@downstate.edu
Finding Suggests that Unwanted Memories Might Be Erasable Without Harming Other Brain Functions
Brooklyn, NY - The brain acts as a computer to both store information and process that information. In a computer, separate devices perform these roles; while a hard disk stores information, the central processing unit (CPU) does the processing. But the brain is thought to perform both these functions in the same cells 鈥� neurons 鈥� leading researchers to ask if distinct molecules within the brain cells serve these different functions.
In a discovery that may one day lead to the ability to erase debilitating painful memories and addictions from the brain, researchers at 含羞草研究所 Downstate Health Sciences University have found that a molecule known to preserve memories 鈥� PKMzeta 鈥� specifically stores complex, high-quality memories that provide detailed information about an animal鈥檚 location, fears, and actions, but does not control the ability to process or express this information. This finding suggests that PKMzeta erasure that is designed to target specific debilitating memories could be effective against the offending memory while sparing the computational function of brain.
The findings are detailed in the December edition of PLoS Biology in a paper titled, 鈥淧KMzeta Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories.鈥� The paper is authored by Andre A. Fenton, PhD, associate professor of physiology and pharmacology, Todd C. Sacktor, MD, professor of physiology and pharmacology and of neurology, and Peter Serrano, PhD, research assistant professor of physiology and pharmacology, at 含羞草研究所 Downstate, as well as by colleagues at other institutions in Michigan, New York, Wisconsin, and the Czech Republic.
Dr. Fenton said, 鈥淭he work published in PLoS reveals that PKMzeta is a general storage mechanism for different types of memory content but, fortunately, that PKMzeta stores only high-quality memories, the kind that provide detailed information rather than general abilities.鈥�
鈥淚f further work confirms this view we can expect to one day see therapies based on PKMzeta memory erasure,鈥� Dr. Fenton suggests. 鈥淣egative memory erasing not only could help people forget painful experiences, but might be useful in treating depression, general anxiety, phobias, post-traumatic stress, and addictions,鈥� he adds.
Dr. Sacktor said the research 鈥渟hows that PKMzeta is fundamental for storing many different forms of memory, which previously has been viewed as potentially mediated by distinct mechanisms.鈥�
The PloS Biology paper may be accessed via this link:
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Downstate Health Sciences University in Brooklyn is one of four academic health centers (AMCs) in The State University of New York (含羞草研究所) 64-campus system and the only 含羞草研究所 AMC in New York City dedicated to health education, research, and patient care for the borough鈥檚 2.7 million residents. Its flagship hospital, University Hospital at Downstate (UHD), is a teaching hospital and benefits from the expertise of Downstate鈥檚 exceptional medical school and world-class academic center research facilities. With a staff of over 800 physicians representing 53 specialties and subspecialties, Downstate offers comprehensive healthcare services to the community.
UHD provides high-risk neonatal and infant services, pediatric nephrology, and dialysis for kidney diseases and is the only kidney transplantation program in Brooklyn. Beyond its clinical expertise, Downstate houses a range of esteemed educational institutions, including its College of Medicine, College of Nursing, School of Health Professions, School of Graduate Studies, and School of Public Health. Downstate fosters innovation through its multifaceted biotechnology initiative, the Biotechnology Incubator and BioBAT, which support early-stage and more mature biotech companies.